the authors should note that previous reports of aaa as an aid to the diagnos** of alzheimer's d**ease h**e been limited largely to studies of normals and patients diagnosed with alzheimer's d**ease.作者(们)应该注意到,以前为帮助诊断阿尔茨海默病的aaa报告在很大程度上局限于对正常人和阿尔茨海默病患者的研究。they correctly state that we h**e little to no **rmation on the level of aaa in mci, and thus little indication of whether or not th** ** an early marker.报告正确地指出,我们对mci (轻度认知障碍)中的aaa水平知之甚少甚至全然不知,因此也难以表明这是否是一种早期标记。the other important **rmation m**sing from th** review ** the specificity of aaa for alzheimer's d**ease compared to other causes of dementia.这篇评论缺少的其他重要信息是,与其它其他原因引起的老年痴呆症相比,阿尔茨海默氏病中aaa的特异性。anecdotal **rmation, widely d**cussed some years ago, suggested that aaa was elevated whenever there was organic brain damage, regardless of the cause.前些年广泛议论的趣闻提出,每当有大脑损伤,无论什么原因,aaa均会升高。th** was certainly true of csf measurements, where elevated aaa accompanied stroke, pa**nson's d**ease, huntington's d**ease and cjd. the urinary test was marketed with th** data in mind, and it was said that a normal level of aaa was able to rule out alzheimer's d**ease - and indeed it did.这对csf (脑脊液)测量来说肯定是真的,其中aaa升高会伴有中风,帕金森氏病,亨廷顿氏病和克雅氏病【注:我觉得cjd[=creutzfeldt-jakobd**ease]是克雅(氏)病:皮层-基底节-脊髓变性症候群;而疯牛病是bovine sponglform encephalopathy(bse)】。尿测试将这个数据标注于心【注:我觉得marketed应该是marked,请确认】,而且,据说正常水平的aaa可以排除阿尔茨海默病---而事实也的确如此。in the absence of brain injury or degeneration, the level was normal, but there was absolutely no specificity for alzheimer's d**ease in compar**on to other causes of dementia.当没有出现脑损伤或退化的情况下,(aaa)的水平是正常的,但与其他老年痴呆症的成因相比,绝对没有阿尔茨海默病的特异性。th** c**eat needs to appear in th** review, to prevent researchers who don't know the h**tory of th** marker from pursuing a dead end.这篇评论中需要有这个附加说明,以免不知这个标记的历史的研究人员钻入死胡同。 20210311
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